Biomedical Engineering Reference
In-Depth Information
issue will likely be to present VEGF in the context of other growth factors, as
the concerted sequential interplay of multiple factors is critical to blood vessel
formation, and tissue regeneration more broadly.
Finally, normal tissue repair is based on elaborate spatiotemporal interac-
tions between the growth factors, cells, the host ECM, and mechanical signals,
and it may be necessary to create polymer systems that enable the interplay
of these multi-components in an appropriate manner. Depending on the af-
fected tissue type (e.g., blood vessels vs. bone), the patient (e.g., aged patients
with fewer competent cells vs. young patients), and the form of tissue dam-
age (e.g., acute injury or degenerative disease), different strategies of VEGF
delivery and different polymeric systems may be needed.
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