Self-Assembling Nanopeptides Become a New Type of Biomaterial - Advances in Polymer Science - page 145

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Self-Assembling Nanopeptides
Become a New Type of Biomaterial

Xiaojun Zhao 1 ( ) · Shuguang Zhang 2

1 Institute for NanoBiomedical Technology and Membrane Biology, West China Hospital,
Sichuan University, Research Building No 1, West China Hospital Science Park No 4 ,
Gao Peng Rd., 610041 Chengdu, China
[e-mail]
2 Center for Biomedical Engineering, Center for Bits and Atoms,
Massachusetts Institute of Technology, 500 Technology Square,
Cambridge, MA 02139-4307, USA

1 I tr cti n ................................... 146

1.1 The Nature's Building Blocks at the Molecular Scale and Design,

SynthesisandFabrication............................ 146

1.2 A Fabrication Tool:

NanobiotechnologyThroughMolecularSelf-Assembly............ 147

1.3 Basic Engineering Principles for Micro- and Nano-Fabrication

BasedonMolecularSelf-AssemblyPhenomena................ 147

1.4 Both Chemical Complementarity and Structural Compatibility

forBionanotechnology ............................. 147

2 Self-Assembly Peptide Systems ......................... 148

2.1 PeptidesasConstructionMotifs ........................ 149

2.2 ModulusI:“PeptideLego” ........................... 149

2.3 MolecularSwitches ............................... 150

2.4 PeptideInk.................................... 151

2.5 PeptideSurfactants/Detergents......................... 152

2.6 OtherSystems .................................. 153

3 Fabrication of Nanomaterials Through Self-Assembling Systems ...... 153

3.1 Nanofibers .................................... 153

3.1.1 Nanofibrils from α -helices ........................... 154

3.1.2 Nanofibrils from β -strands........................... 155

3.2 BionanotubesandVesicles ........................... 155

3.2.1 ShortAmphiphilicPeptides........................... 155

3.3 Nanometer-Thick ................................ 157

3.4 Nanowires .................................... 158

3.4.1 FromNanotubetoNanowire.......................... 159

3.4.2 TemplatesforNanowires:DNAforNano-Electronics............. 160

3.5 OtherNanomaterials .............................. 161

4 Application of Self-Assembling Systems .................... 161

4.1 SimplePeptidesStabilizeMightyMembraneProteinsforStudy....... 161

4.2 TissueEngineering ............................... 162