Biomedical Engineering Reference
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Fig. 1.18
In vivo
Raman spectra of cutaneous melanin obtained under 785-nm laser excitation
from (
a
) volar forearm skin of a volunteer of African descent, (
b
) benign compound pigmented
nevus, (
c
) malignant melanoma, and (
d
) normal skin site adjacent to the malignant melanoma.
Also shown at the
right
side are clinical images of the corresponding skin sites for
in vivo
Raman
measurements (Adapted from Huang et al. [
62
], with permission)
1.0
MM
BCC
SCC
SK
AK
AN
CN
IN
JN
0.8
0.6
0.4
0.2
0.0
600
800
1000
1200
1400
1600
Raman shift (cm-1)
Fig. 1.19
Normalized Raman spectra of skin cancers and benign skin diseases, including
melanoma (
MM
), basal cell carcinoma (
BCC
), squamous cell carcinoma (
SCC
), seborrheic
keratosis (
SK
), actinic keratosis (
AK
), atypical nevus (
AN
), compound nevus (
CN
), intradermal
nevus (
IN
), and junctional nevus (
JN
) (Adapted from Zhao et al. [
61
], with permission)
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