Multimodal Diffuse Optical Imaging - Biomedical Optical Imaging Technologies: Design and Applications - page 364

Fig. 10.5 ( a ) Prototype of the handheld combined NIR/US imager developed in the University
of Connecticut. ( b ) The entire imaging volume is segmented into lesion (L) and background (B)
regions. The fine imaging grid is used for the lesion region, and the coarse grid is used for the
background. ( c ) NIR/US images of a nonpalpable lesion in a 55-year-old woman. US showed
a nodular mass with internal echoes, and the lesion was considered suspicious. The maps of total
hemoglobin concentration distribution correspond to slices from 0.7 cm underneath the skin surface
to the chest wall, with 0.5-cm spacing. The lesion is well resolved in slice 5 (Used with permission
from [ 70 ])

tissues are segmented in a coarser grid. An example of a clinical dual-modality
examination is provided in Fig. 10.5 . An 8-mm suspicious lesion identified on the
US was showing a significant increase in total hemoglobin concentration ( 10-
fold) compared to the background tissue. The lesion was diagnosed as an infiltrating
ductal carcinoma which was supporting the finding of the optical readings.

10.5.4 Positron Emission Tomography (PET)

The primary goal of combining diffuse optical imaging with other clinical modal-
ities is to benefit from the structural information provided by the high-resolution
imaging modalities in order to improve upon functional potential of DOI. In
particular, the structural details acquired using MRI, US, and X-ray imaging are
used as a priori information to guide the optical reconstructions that suffers from