Biomedical Engineering Reference
In-Depth Information
Chapter 10
Multimodal Diffuse Optical Imaging
Xavier Intes, Vivek Venugopal, Jin Chen, and Fred S. Azar
Diffuse optical imaging, particularly diffuse optical tomography (DOT), is an
emerging clinical modality capable of providing unique functional information, at
a relatively low cost, and with nonionizing radiation. Multimodal diffuse optical
imaging has enabled a synergistic combination of functional and anatomical
information: the quality of DOT reconstructions has been significantly improved
by incorporating the structural information derived by the combined anatomical
modality. In this chapter, we will review the basic principles of diffuse optical imag-
ing, including instrumentation and reconstruction algorithm design. We will also
discuss the approaches for multimodal imaging strategies that integrate DOI with
clinically established modalities. The merit of the multimodal imaging approaches is
demonstrated in the context of optical mammography, but the techniques described
herein can be translated to other clinical scenarios such as brain functional imaging
or muscle functional imaging.
10.1
Introduction
Advances in clinical imaging are being made through the combination of imaging
techniques and multimodal imaging platforms, such as PET/CT, PET/MRI,
and MRI/US. More recently, optical imaging methods have been used in
multimodal imaging platforms such as MRI/DOT (diffuse optical tomography),
X. Intes (
)
J. Chen
Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
e-mail:
intesx@rpi.edu
F.S. Azar
Clinical Data Solutions, Office of Medical & Health Affairs, Philips Healthcare, Ramsey,
NJ 07446-2709, USA
V. Venugopal
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