Biomedical Engineering Reference
In-Depth Information
Chapter 1
Advanced Spectroscopy Technique
for Biomedicine
Jianhua Zhao and Haishan Zeng
This chapter presents an overview of the applications of optical spectroscopy in
biomedicine. We focus on the optical design aspects of advanced biomedical spec-
troscopy systems, Raman spectroscopy system in particular. Detailed components
and system integration are provided. As examples, two real-time
in vivo
Raman
spectroscopy systems, one for skin cancer detection and the other for endoscopic
lung cancer detection, and an
in vivo
confocal Raman spectroscopy system for
skin assessment are presented. The applications of Raman spectroscopy in cancer
diagnosis of the skin, lung, colon, oral cavity, gastrointestinal tract, breast, and
cervix are summarized.
1.1
Introduction
Spectroscopy is a technique for studying the wavelength-dependent optical signals.
A spectroscopy system or a spectrometer generally consists of five components:
the illumination/excitation light source, the illumination/excitation light delivery
unit, the response light collection unit, the spectrograph to separate wavelength-
dependent response light, and a detection unit to convert the light signal into
electrical signals and/or digital data. In a modern spectrometer, a computer is often
used to control the whole system and perform spectral and intensity calibrations as
well as data processing.
J. Zhao
H. Zeng (
)
Imaging Unit - Integrative Oncology Department, British Columbia Cancer Agency Research
Center, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada
Photomedicine Institute, Department of Dermatology and Skin Science, University of British
Columbia & Vancouver Coastal Health Research Institute, 835 West 10th Avenue, Vancouver, BC
V5Z 4E8, Canada
e-mail:
hzeng@bccrc.ca
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