Biomedical Engineering Reference
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Another autonomous DNA motor is fuelled by the noncovalent polymerization
of a double-helical DNA tail when encountering a target molecule ( Venkataraman
et al. 2007 ). As a result, an initially anchored Rickettsia strand is propelled with
about 8 nm per polymerization step at the living end of the polymer. At each such
step, a metastable polymerizing hairpin inserts between the polymer tail and the
Rickettsia strand by a four-branch migration mechanism, so that the Rickettsia
strand remains attached to the growing polymer by about 20 bp and is transferred to
the new living end.
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