Nanomedicine - Bionanoelectronics: Bioinquiring and Bioinspired Devices - page 130

agent flow

reservoir
25 nl small opening

large opening

Fig. 4.2 The reservoir (the top is the gold anode)

cathode cathode

V = 0V

V = 1.04 V

agent release

Fig. 4.3 The reservoir in the two states

drug release
microchip

antenna

battery

Ti-case

Fig. 4.4 RF-implantable controlled drug release system

mannitol, and one chemotherapeutic agent, carmustine (BCNU). Subcutaneous
release was performed in rats, and the spatial profile of fluorescein dye release
was monitored by fluorometry, while the temporal profile of mannitol release func-
tionalized with 14 C was observed by liquid scintillation counting ( Li et al. , 2004 ).
The release profile of the BCNU functionalized with 14 C was measured with an