QCS-008 - Quality Operations Procedures for Pharmaceutical, API, and Biotechnology - page 21

SOP No. QCS-008.00 Effective date: mm/dd/yyyy
Approved by:

• Flush the sanitary sampling valve port thoroughly, and then close the valve.
• Remove the yellow and blue stoppers and attach them to the base.
• Fit the MicropreSure outlet to the receiving graduated container, or connect a length of
tubing to the device outlet.

• Insert the sampling valve port outlet into the MicropreSure inlet and, with a slight twisting
movement, push the MicropreSure device onto the valve.
• Close the sampling valve when the desired sample volume or the desired sampling time
has been reached.
• Gently pull the MicropreSure device away from the valve, using a rotating movement.
Maintain the device in a horizontal position.
• Place the yellow stopper over the MicropreSure device outlet and use the blue stopper to
seal the device inlet.
• Record the sample location, time, and volume on the side of the MicropreSure dome and
send to the laboratory for processing.

• Access the membrane by connecting the MSOpener™ to a vacuum source, and placing the
MicropreSure In-Line Filtration Sampler on top of the MSOpener.

• Incubate the membrane by lifting the membrane and transferring it onto a media plate.