Biomedical Engineering Reference
In-Depth Information
O
O
Cl
Br
N
NH
N
O
3.11
3.2
FIGURE 3.5
Superimposition of compounds
3.11
and
3.2.
O
Cl
NO
2
O
NO
2
O
N
Br
Br
NH
NH
N
O
O
O
O
O
O
3.5
Initial template molecule
3.12
New template molecule
3.11
Hydrogen-bond donor
Shape
FIGURE 3.6
Compound
3.11
, the initial template molecule
3.5
, the new template molecule
3.12
, and
the updated pharmacophore model with the new hydrogen-bond donor pharmacophore element (magenta)
included.
