Biomedical Engineering Reference
In-Depth Information
O
O
O
N
N
N
HN
HN
HN
N
N
N
N
N
H
2
N
N
H
2
N
H
2
N
O
C
HO
HO
H
2
N
C
O
O
O
CH
CH
3
H
3
C
OH
Acyclovir
Valaciclovir
Penciclovir
O
O
N
N
I
CF
3
HN
HN
N
H
2
N
N
O
N
O
N
O
HO
HO
O
O
O
H
3
C
OH
OH
H
3
C
O
Idoxuridine
Triluridine
O
O
Famciclovir
Br
HN
O
N
HO
O
OH
Brivudin
FIGURE 24.11
Structures of a number of antiherpes simplex virus (anti-HSV) and antivaricella-zoster virus
(anti-VZV) compounds.
24.4.1.3 Penciclovir
Structure
(Figure 24.11): 9-(4-Hydroxy-3-hydroxymethyl-but-1-yl)guanine (PCV), Denavir
®
, Vectavir
®
.
Activity spectrum
: HSV 1, HSV-2, and VZV.
Mechanism of action
: Essentially similar to that of acyclovir.
Principal indication(s)
: Mucocutaneous HSV infections, particularly recurrent herpes labialis
(cold sores).
Administered
: Topically as a 1% cream.
24.4.1.4 Famciclovir
Structure
(Figure 24.11): Diacetyl ester of 9-(4-hydroxy-3-hydroxymethyl-but-1-yl)-6-deoxyguanine
(FCV), Famvir
®
.
