Biomedical Engineering Reference
In-Depth Information
24
Antiviral Drugs
Erik De Clercq
CONTENTS
24.1 Introduction......................................................................................................................... 394
24.2 Anti-HIVCompounds ......................................................................................................... 394
24.2.1 Nucleoside Reverse Transcriptase Inhibitors (NRTIs) .......................................... 394
24.2.1.1 Zidovudine ............................................................................................. 394
24.2.1.2 Didanosine.............................................................................................. 395
24.2.1.3 Zalcitabine.............................................................................................. 396
24.2.1.4 Stavudine................................................................................................ 396
24.2.1.5 Lamivudine............................................................................................ 397
24.2.1.6 Abacavir................................................................................................. 397
24.2.1.7 Emtricitabine.......................................................................................... 397
24.2.2 Nucleotide Reverse Transcriptase Inhibitors (NtRTIs).......................................... 397
24.2.2.1 Tenofovir Disoproxil.............................................................................. 397
24.2.3 Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) ................................. 399
24.2.3.1 Nevirapine.............................................................................................. 399
24.2.3.2 Delavirdine.............................................................................................400
24.2.3.3 Efavirenz................................................................................................400
24.2.4 Protease Inhibitors (PIs).........................................................................................400
24.2.4.1 Saquinavir...............................................................................................400
24.2.4.2 Ritonavir.................................................................................................400
24.2.4.3 Indinavir.................................................................................................402
24.2.4.4 Neli navir................................................................................................402
24.2.4.5 Amprenavir ............................................................................................402
24.2.4.6 Lopinavir................................................................................................ 403
24.2.4.7 Atazanavir.............................................................................................. 403
24.2.4.8 Fosamprenavir........................................................................................ 403
24.2.4.9 Tipranavir............................................................................................... 403
24.2.4.10 Darunavir ............................................................................................... 403
24.2.5 Viral Entry Inhibitors ............................................................................................404
24.2.5.1 Enfuvirtide.............................................................................................404
24.3 Anti-HBVCompounds ........................................................................................................404
24.3.1 Lamivudine............................................................................................................404
24.3.2 AdefovirDipivoxil.................................................................................................404
24.3.3 Entecavir................................................................................................................406
24.3.4 Telbivudine.............................................................................................................406
24.4 AntiherpesvirusCompounds..............................................................................................406
24.4.1 HSV and VZV Inhibitors.......................................................................................406
24.4.1.1 Acyclovir................................................................................................406
393
