Biomedical Engineering Reference
In-Depth Information
13.6 LIGAND-GATED ION CHANNELS
Na
v
and K
v
channels are essential for generation and conduction of neuronal action potentials and
Ca
v
channels are essential for converting action potentials into neurotransmitter release—but it
is the ligand-gated ion channels which receive the chemical signals of synaptic transmission and
convert them into the electrical signals that initiate action potentials. See Chapter 12 for further
details about ligand-gated ion channels.
FURTHER READINGS
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P. 2002.
Molecular Biology of the Cell
,
4
th
edn. Garland Publishing Inc., New York.
Ashcroft, F. 2000.
Ion Channels and Disease
. Academic Press, London, U.K.
Catterall, W.A. 2000. From ionic currents to molecular mechanisms: The structure and function of voltage-
gated sodium currents.
Neuron
26: 13-25.
Catterall, W.A. et al. 2005. International Union of Pharmacology. Compendium of voltage-gated ion channels.
Pharmacol. Rev
. 57: 385-540.
Catterall, W.A. et al. 2007. Voltage-gated ion channels and gating modii er toxins.
Toxicon
49: 124-141.
Dalby-Brown, W., Hansen, H., Korsgaard, M.G., Mirza, N., and Olesen, S.-P. 2006. Kv7 channels: Function,
pharmacology and channel modulators.
Curr. Top. Med. Chem
. 6: 999-1023.
Doyle, D.A., Cabral, J.M., Pfuenzner, R.A., Kuo, A., Gulbis, J.M., Cohen, S.L., Chait, B.T., and MacKinnon, R.
1998. The structure of the potassium channel: Molecular basis of K
+
conduction and selectivity.
Science
280: 69-77.
Hille, B. 2001.
Ionic Channels of Excitable Membranes
. 3rd edn. Sinauer Associates, Sunderland, MA.
Nardi, A. and Olesen, S.-P. 2008. BK channel modulators: A comprehensive overview.
Curr. Med. Chem
. 15:
1126-1146.
Nilius, B., Owsianik, G., Voets, T., and Peters, J.A. 2007. Transient receptor potential cation channels in disease.
Physiol. Rev
. 87: 165-217.
Sanguinetti, M.C. and Tristani-Firouzi, M. 2006. Herg potassium channels and cardiac arrhythmia.
Nature
440:
463-469.
