Biomedical Engineering Reference
In-Depth Information
in terms of efi cacy, safety, and drugability, the prodrug principle offers opportunities for a
temporarily change and improvement of physicochemical, pharmaceutical, biopharmaceutical,
and ADME properties of a pharmacologically active molecule. The prodrug principle constitutes a
tool for building additional properties into interesting pharmacologic active molecules, which are
of vital importance for the development of clinically useful drugs. Thus, integration of prodrug
considerations into the drug design paradigm may increase the opportunity for discovery and
development of novel innovative drugs and treatment concepts to the benei t of patients.
FURTHER READINGS
Bundgaard, H. (Ed.). 1985.
Design of Prodrugs
. Elsevier, Amsterdam.
Bundgaard, H. 1989. Themed issue. Prodrugs for improved drug delivery.
Adv. Drug Deliv. Rev
. 3(1), 1-154.
Sloan, K.B. (Ed.). 1982.
Drugs and the Pharmaceutical Science Vol. 53. Prodrugs: Topical and Ocular Drug
Delivery
. Taylor & Francis, Boca Raton, FL.
Stella, V.J. 1996. Themed issue. Prodrugs.
Adv. Drug Deliv. Rev
. 19(2), 111-330.
Stella, Valentino J., Borchardt, Ronald T., Hageman, Micahel J., Oliyai, Reza, Maag, Hans, and Tilley, Jefferson W.
(Eds.). 2007.
Prodrugs: Challenges and Rewards Part 1 and 2
. 1st edition, Springer, New York.
