Biomedical Engineering Reference
In-Depth Information
OCH 3
HO
OCH 3
NOMe
O
O
H
O
O
O
O
H
O
O
O
O
O
O
OH
OH
O
O
OH
OH
Ivermectin B 1a
Moxidectin
FIGURE 6.4
Antiparasitic milbemycin analogs.
Sar
Sar
Pro
Pro
OH
(Me)Val
O
O
(Me)Val
OH
Val-D
Val-D
O
O
Thr
Thr
HN
O
O H
O
O
OCH 3
OH
N
NH 2
O
NH 2
O
O
OH
Actinomycin D
Doxorubicin
NH 2
N
O
O
NH 2
NH 2
R
N
O
NN
S
N
O
N
OHO
H 2 N
H
S
HN
O HO
H
N
O
HO
+
O
R =
HN
S
O
H
HO
OH
OH
O
OH
O
OH
Bleomycin A 2
O
NH 2
FIGURE 6.5
Cytotoxic antibiotics.
6.4 SCREENING
6.4.1 G ENERAL C ONCEPTS
In the most general sense screening refers to the process of investigating sources of compounds
that exhibit a particular type of property or biological activity. In this chapter, we are exploring
ways of using natural products for drug discovery, and therefore the “investigations” are typically
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