Biomedical Engineering Reference
In-Depth Information
Measurement
Environment
Personnel
pH
Conductivity
Training
Flow rate
Experience
Temperature
UV
Packing skills
Air quality
Critical quality
attributes
Column packing
Linear gradient
Resin capacity, particle size, etc.
Column
Step gradient
Counter-ion
System design
Flow through
Buffer ion
pH, conductivity
Machine
Method
Materials
Figure
13.5. Ishikawa diagram, illustrating relationship of various parameters impacting a chro-
matography unit operation.
