Biomedical Engineering Reference
In-Depth Information
typically preprocessed to reduce these types of noise due to bioreactor conditions
associated with stirring and aeration (Fig. 12.1a).
The “smoothed” data (Fig. 12.1b) are then correlated with off-line data and using
partial least squares models to build calibration and validation data sets, so that
subsequent probe analyses will quantify the analyte of interest from the calibration set.
When introducing this technology into regulated manufacturing areas, validation of the
Figure
12.1. (a) Low pass filter shows overall reduction of noise. (b) Savitzky-Golay smoothing
shows similar noise reductionbut requires thealgorithmtobe runwhenevaluationeach spectra.
