Biomedical Engineering Reference
In-Depth Information
Figure
6.10.
Determining the optimum concentration to perform diafiltration.
TABL E 6.1. Comparison of Different Concentration/Diafiltration Combinations
for Processing Albumin. Objective 5
Concentration and 5
Diafiltration
Average
Flow Rate
(L/h)
Batch
Volume (L)
Protein
Conc. (%)
Filtrate
Rate (L/h)
Permeate
Volume (L)
Filtrate
Time (h)
CASE A
Initial
1000
5
940
Conc. 5
200
25
140
460
800
1.7
Diaf. 5
200
25
160
150
1000
6.7
Total
1800
8.4
CASE B
Initial
1000
5
940
Diaf. 5
1000
5
1060
100
5000
5
Conc. 5
200
25
160
520
800
1.5
Total
5800
6.5
CASE C
Initial
1000
5
940
Conc. 5
500
10
600
740
500
0.7
Diaf. 5
500
10
680
640
2500
3.9
Conc. 2.5
200
25
160
370
300
0.8
Total
3300
5.4
