Biomedical Engineering Reference
In-Depth Information
(c)
110
100
90
80
70
140
120
100
80
150
100
50
-
+
Temperature
Total Induction
(induction)
Ramp time
duration
Figure
5.7.
(Continued)
(a)
Term
Scaled estimate
Prob>|t|
Intercept
Temperature (growth)
Feed 1
pH (growth)
(Temperature (growth) -28.7273)*(Feed-1 -0.14773)
(Temperature (growth) -28.7273)*(pH (growth) -7.01364)
(Feed-1 -0.14773)*(pH (growth) -7.01364)
87.116567
-8.952117
5.3665288
-7.292842
-3.143798
1.8746749
7.0808963
<.0001*
0.0002*
0.0294*
0.0051*
0.1570
0.3884
0.0043*
(b)
Term
Scaled estimate
Prob>|t|
Intercept
Temperature (growth)
Feed-1
pH (growth)
(Temperature (growth) -28.7273)*(Feed-1 -0.14773)
(Temperature (growth) -28.7273)*(pH (growth) -7.01364)
(Feed-1 -0.14773)*(pH (growth) -7.01364)
134.76649
27.795386
-25.05927
38.934864
-1.339165
1.2617657
-29.43514
<.0001*
<.0001*
0.0003*
<.0001*
0.7976
0.8090
<.0001*
(c)
Term
Scaled estimate
Prob>|t|
Intercept
Temperature (growth)
Feed-1
pH (growth)
(Temperature (growth) -28.7273)*(Feed-1 -0.14773)
(Temperature (growth) -28.7273)*(pH (Growth) -7.01364)
(Feed-1 -0.14773)*(pH (growth) -7.01364)
136.60686
23.791565
6.2741509
24.028879
5.0111857
-4.594519
-14.98881
<.0001*
0.0034*
0.4736
0.0130*
0.5444
0.5780
0.0834
Figure
5.8.
Scaled estimates of main effects of growth phase operational parameters on
product yield (a), product quality 1 (b), and product quality 2 (c) performance from a full
factorial DOE study. Note: Data have been normalized against the average small-scale model
performance at set point operating conditions.
