Biomedical Engineering Reference
In-Depth Information
(a)
Performance
parameter
Large scale data
Small scale data
SP
NOR
(b)
Performance
parameter
SP
NOR
Figure
5.4.
A successful small-scale model mimics not only the large-scale process performance
at SP operating conditions but also that observed at the edges of (and preferably beyond).
Normal Operating Range (NOR). A. Small-scale model mimics large-scale performance at center
point but deviates if the process is run elsewhere in NOR. B. Small-scalemodel mimics large-scale
performance not only at center point but also in the NOR.
Define small-scale model operating
parameters and control strategies
Identify key and critical small-scale
model performance parameters
Determine acceptable limits
of scale equivalence
Perform small-scale model
consistency runs
Demonstrate scale equivalency
Continuous verification of small-scale
model equivalency and refinement
Figure
5.5.
Small-scale model development and qualification activities.
