Biomedical Engineering Reference
In-Depth Information
Mechanobiological Modelling
of Angiogenesis: Impact on Tissue
Engineering and Bone Regeneration
Esther Reina-Romo, Clara Valero, Carlos Borau, Rafael Rey,
Etelvina Javierre, María José Gómez-Benito, Jaime Domínguez
and José Manuel García-Aznar
Abstract Angiogenesis is essential for complex biological phenomena such as
tissue engineering and bone repair. The ability to heal in these processes strongly
depends on the ability of new blood vessels to grow. Capillary growth and its
impact on human health has been focus of intense research from an in vivo, in vitro
and in silico perspective. In fact, over the last decade many mathematical models
have been proposed to understand and simulate the vascular network. This review
addresses the role of the vascular network in well defined and controlled processes
such as wound healing or distraction osteogenesis and covers the connection
between vascularization and bone, starting with the biology of vascular ingrowth,
E. Reina-Romo (
)
J. Domínguez
Department of Mechanical Engineering, University of Seville,
41092 Seville, Spain
e-mail: erreina@us.es
J. Domínguez
e-mail: jaime@us.es
C. Valero
C. Borau
R. Rey
E. Javierre
M. J. Gómez-Benito
J. M. García-Aznar
Aragon Institute of Engineering Research (I3A),
University of Zaragoza, C/María de Luna 5,
Agustín de Betancourt Building, 50018 Zaragoza, Spain
M. J. Gómez-Benito
e-mail: gomezmj@unizar.es
J. M. García-Aznar
e-mail: jmgaraz@unizar.es
E. Javierre
Centro Universitario de la Defensa, Academia General Militar Ctra,
Huesca s/n, 50090 Zaragoza, Spain
e-mail: etelvina.javierre@unizar.es
&
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