Biomedical Engineering Reference
In-Depth Information
substantially increase uniformity throughout the tissue. The models could also be
extended growth factors, which could further highlight the utility of convective
transport within the tissue since many growth factors are proteins with a typical
diffusivity that is multiple orders of magnitude lower than oxygen [
34
]. The
reaction kinetics are likely different compared to oxygen; regardless, the incor-
poration of convective transport should greatly impact the concentration profile
uniformity because of the much lower diffusivity.
Acknowledgments This work has been supported by National Institutes of Health (NHLBI R01
HL083880 to RTT) and 3M Company (JWB). Furthermore, the technical assistance of Naomi
Ferguson and Lee Meier is gratefully acknowledged as well as Dave Hultman for his efforts in
machining and design discussions.
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