Biomedical Engineering Reference
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Fig. 8 Mini-bioreactor approach developed to validate multiphysics computational models of
cartilage growth. a Exploded view showing (I) bottom side magnetic holder, (II) cover glass, (III)
PDMS perfusion chamber (arrow), (IV) glass slide with CNC-milled perfusion channels, (V) top
side magnetic holder. b Photograph of the mini-bioreactor placed on the microscope, c rendering
of the polystyrene scaffold, d detail of the scaffold regular geometry and e fluorescence live
image of the scaffold seeded with cells, in which cell nuclei stain blue and the cell cytoplasm
stains orange. A coloured version of this figure is available on the online version of the topic
Fig. 9 Integration between experiments and simulation in cartilage tissue engineering.
Fluorescence images of cellular constructs marked with live staining, in which the cell nuclei
stain blue and the cell cytoplasm stains orange, taken a at the beginning and b the end of culture,
compared to c, d the numerical output of the multiphysics model [ 43 ]. In (c) and (d) the wall fluid
shear stress is mapped on the biomass surface (c) at the beginning and (d) the end of culture.
e The 3D domain modeled
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