Biomedical Engineering Reference
In-Depth Information
Shape factor < 0.621
Shape factor >=0.621
Total_arera >=171.5
Total_area < 171.5
hole_area < 10
hole_area >=10
Fiber_length < 60.3
Fiber_length>=60.3
Fiber_l< 33.54
Fiber_l>=33.54
Total_a>=99.5
Total_a< 99.5
K_h
0/0/0/0/0/99/0/0/0
Total_area
>=488.5
Breadth
>=9.011
Breadth
< 9.011
Total_area
< 488.5
F_s
0/8/87/0/2/0/0/1/0
N_l
8/0/1/0/0/0/0/84/1
K_n
1/0/3/0/97/0/0/0/0
K_s
0/0/0/0/0/0/99/0/2
F_n
0/80/6/18/0/0/0/9/0
F_o
0/12/0/82/0/0/0/0/0
K_c
85/0/3/0/1/1/1/1/17
N_s
6/0/0/0/0/0/0/5/80
Fig. 9 Structure of the cell contamination evaluation model. The selected parameters are
described in each node. Under the terminus of branches, bars indicate the percentage of all cell
objects in the terminal node. The numbers separated by slashes indicates the object numbers
clustered at the end branch
another ''sub-population of objects'' which has similar morphology and disrupts
the classification accuracy. Such sub-populations are individually assigned in the
decision tree model; therefore, it provided the highest accuracy in classifying the
two cell types at the single cell level.
6 Discussion
Although some reports have described a connection between ''morphology'' and
''cell quality,'' few reports focus on the practical tasks and problems associated with
clinical cell therapy or demonstrate the effectiveness of various machine learning
model approaches. Therefore, in this chapter, we have reviewed some of our
successful studies on image-based bioinformatics modeling in clinical cell therapy.
Image-based cell assessment is gaining popularity along with the advances in
''imaging equipment'' and ''high content analysis software.'' Indeed, machine
learning approaches are important for the analysis of ''multi-variant data mea-
surements'' together with ''biological complex phenomena.'' Bioinformatics,
widely applied in the research fields of DNA microarray, SNP typing, and pro-
teome data mining, has been the leading application in the field of machine
learning algorithms. Image-based data analysis may be the next frontier.
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