Biomedical Engineering Reference
In-Depth Information
Chapter 7
Nanopharmacology
Chapter Outline
7.1 Introduction
293
7.4.5 NMs for Vaccine
Delivery
7.2 Current Issues and Status
of Nanopharmacology
319
294
7.5 NM
s
for Thermal Ablation
321
7.3 NM
s
for Gene Delivery
297
7.5.1 Thermal Ablation
Using MNPs
7.3.1 Gene Delivery
with Inorganic NMs
323
298
7.5.2 Thermal Ablation
and NMs Combination
Therapeutics
7.3.2 Gene Delivery with
Biodegradable
Polymers
324
300
7.6 NMs as Contrast Agents
326
7.3.3 Electrostatic Loading
of DNA in NMs
7.6.1 NMs Contrast Agents in
Clinical Use
302
327
7.4 Nanoimmunotherapy
304
7.6.2 NMs as Imaging Contrast
Agents in Preclinical
Development
7.4.1 Protocol for the
Preparation of Chitosan
IFN-
γ
pDNA NPs and
Green Fluorescent Protein
Test of Expression
330
7.7 Magnetic IO NP-mediated
Circulating Tumor Cell
Isolation
307
334
7.4.2 The Use of Ceramic
Core NPs as Delivery
Systems
for Immunotherapy
7.7.1 IO-Ab Separation of
Cancer Cells in Spiked
Fresh Human Whole
Blood
308
336
7.4.3 NMs for Tumor
Immunotherapy
7.8 Design Trends for
Individualized Medicine
314
340
7.4.4 Release of Anti-CD40
and CpG from
Liposomes In vitro
7.9 Conclusions
342
317
7.1 INTRODUCTION
Nanoparticles (NPs) can be engineered to diagnose conditions and recognize
pathogens; identify ideal pharmaceutical agents to treat the condition or patho-
gens; fuel high-yield production of matched pharmaceuticals (potentially in
