Biomedical Engineering Reference
In-Depth Information
a
0 sec
1 sec
4 sec
30
m
m
b
0 sec
10 sec
20 sec
50
m
m
c
200
m
m
Fig. 2.6
(
a
) Two cells are positioned using the integrated circuit's pixel display. (
b
)Arat
macrophage and a yeast cell are positioned. (
c
) Yeast cells are arranged into a complex pattern
spelling out “Lab on a Chip,” the title of the journal where this work was first published
blood, urine, cells, and other human samples. The resulting reactants are positioned
over sensing regions of the chip for analysis. The positioning process must be
capable of multiplexing hundreds of droplets simultaneously and without collisions
to allow multiple diagnostic tests to be performed in parallel.
Figure
2.6
shows cells and droplets being trapped and positioned using a hybrid
integrated circuit/microfluidic chip. A cell is trapped over an active pixel and
positioned by shifting the pixel's voltage onto neighboring pixels [
14
]. Cells and
droplets follow the electric field maximum as it moves from pixel to pixel. Figure
2.6
