Biomedical Engineering Reference
In-Depth Information
Fig. 1.5
(
a
) Cepheid's GeneXpert test platform (
right
) integrates sample processing and PCR
in a disposable plastic cartridge (
left
) containing reagents for cell lysis, nucleic acid extraction,
amplification and amplicon detection. This system has been used to detect drug-resistant tubercu-
losis cases (Taken from www.cepheid.com with permission from Cepheid, Inc.) (
b
) Nanosphere
Verigene system. Picture of a Nanosphere cartridge with loaded reagent wells (
left
). Picture of
Verigene readers with touch-screen control panels (
right
) (Taken from www.nanosphere.us with
permission from Nanosphere, Inc.)
Other commercial effort toward a point-of-care nucleic acid device includes
Spartan RX CYP2C19, by Spartan Bioscience, which is the first point-of-care
genetic testing system to receive the CE marking from the European regulatory
health authorities [
53
]. T2 Biosystems is based on magnetic resonance signal
detection from nanoparticles coupled with target analytes which does not require
sample purification; therefore, rapid turnaround time can be achieved.
