Biomedical Engineering Reference
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Fig. 1.5 ( a ) Cepheid's GeneXpert test platform ( right ) integrates sample processing and PCR
in a disposable plastic cartridge ( left ) containing reagents for cell lysis, nucleic acid extraction,
amplification and amplicon detection. This system has been used to detect drug-resistant tubercu-
losis cases (Taken from with permission from Cepheid, Inc.) ( b ) Nanosphere
Verigene system. Picture of a Nanosphere cartridge with loaded reagent wells ( left ). Picture of
Verigene readers with touch-screen control panels ( right ) (Taken from with
permission from Nanosphere, Inc.)
Other commercial effort toward a point-of-care nucleic acid device includes
Spartan RX CYP2C19, by Spartan Bioscience, which is the first point-of-care
genetic testing system to receive the CE marking from the European regulatory
health authorities [ 53 ]. T2 Biosystems is based on magnetic resonance signal
detection from nanoparticles coupled with target analytes which does not require
sample purification; therefore, rapid turnaround time can be achieved.
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