Biomedical Engineering Reference
In-Depth Information
Chapter 7
Magneto-Nanosensor Diagnostic Chips
Richard S. Gaster, Drew A. Hall, and Shan X. Wang
Abstract
We have developed an automated assay for disease biomarker detection
that can be run on a handheld sensing platform. By coupling magnetic nanotech-
nology with an array of magnetically responsive nanosensors, we demonstrate a
rapid, multiplex immunoassay that eliminates the need for trained technicians to
run molecular diagnostic tests. A major limitation for other detection modalities
is signal distortion that occurs due to background heterogeneity in ionic strength,
pH, temperature, and autofluorescence. Here, we present a magnetic nanosensor
technology that is insensitive to background yet still capable of rapid, multiplex
protein detection with resolution down to attomolar concentrations and extensive
linear dynamic range. The insensitivity of our detector to various media enables our
technology to be directly applied to a variety of settings such as molecular biology
and clinical diagnostics.
R.S. Gaster
Department of Bioengineering, Medical Scientist Training Program, School of Medicine,
Stanford, CA 94305, USA
D.A. Hall
Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
e-mail:
drewhall@UCSD.EDU
S.X. Wang
Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
Department of Materials Science and Engineering, Stanford University, Stanford,
CA 94305, USA
e-mail:
sxwang@stanford.edu
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