GrpE, Hsp110/Grp170, HspBP1/Sil1 and BAG Domain Proteins: Nucleotide Exchange Factors for Hsp70 Molecular Chaperones - The Networking of Chaperones by Co-chaperones - page 5

Fig. 1.2 Structure and mechanism of nucleotide exchange factors Structures for the four NEF
families are shown together the respective Hsp70 complexes. The NEF is always shown in green ;
the Hsp70 NBD in blue with subdomain IIB highlighted in beige . On the right the structure of the
NBD in the complex is superposed with the ADP-bound conformation, and the putative nucleo-
tide exchange mechanism indicated. For comparison, the structure of the NEF-antagonist Hip
is shown. The drawings are based on the PDB coordinate sets 1DKG (GrpEﾷDnaK (Harrison