G Protein-Coupled Receptor Transactivation: From Molecules to Mice - Methods in Cell Biology - page 432

(I) Hypothalamus

GnRH

Pituitary gonadotrope

LH

LH

Testes

Cholesterol

StAR

Cholesterol

Pregnenolone

Leydig cell

Cyp17a1

DHEA

- Spermatogenesis
- Seminiferous tubule diameter
- Sexual function/fertility
- Anabolic effects on extra-gonadal
tissue
- Reproductive tract weight

Testosterone

(II)

FIGURE 23.4
Mode of functional rescue by LHCGR transactivation in vivo (I): actions of LH/hCG via LHCGR.
LH binding to LHCGR induces the expression of StAR and CYP17a1. Dashed lines represent
pathways with intermediate steps not shown. (II) Morphology and histology of male
reproductive tract and testis of (a) homozygous LuRKO, (b) homozygous LuRKO/LHCGR B ,
(c) homozygous LuRKO/LHCGR S , (d) homozygous LuRKO/LHCGR B /LHCGR S , and
(e) WT animals. Immunofluorescence shows localization of Lhcgr B (green) and
Lhcgr S (red).

Edited from Rivero-Mu¨ller et al. (2010) .