Biology Reference
In-Depth Information
FIGURE 7.1
Mouse 5-HT
4
variants and key mutants receptors used. (A) Scheme of the mouse 5-HT
4
receptor showing the four splice variants differing in length and composition after a common
splicing site (vertical bar). Position of
△
327 mutant, devoid of the C-terminal domain of
the receptor, is depicted by a double-head arrow. D
100
A mutation is indicated with a
dark-blue plain circle. (B) Pharmacological profile of the wild-type 5-HT
4
receptor (WT) and of
the D
100
A mutant. Both receptors are activated by the full agonist BIMU8, whereas only
the WT receptor is capable to respond to the endogenous ligand serotonin (5-HT). 5-HT is
unable to bind into D
100
A mutant.
