Biomedical Engineering Reference
In-Depth Information
(a)
V
(b)
Inner dope
(c)
Coaxial needles
spinneret
Outer dope
Composite jet
Bi-component
nanofibers
FIGURE 5.2
Schematics of electrospinning. (a) Random nanofibers produced by static
collector. (b) Aligned nanofibers produced on a disk collector in a rotating wheel. (c) Coaxial
electrospinning model for producing core-shell nanofibers.
Tissue engineering involves scaffolds or matrices to provide support for cells in order
to express new ECM. The biocompatibility of scaffold materials actively participates
in the signaling process for the requirement of safe degradation and provides a
substratum for cell migration into the defect sites of the tissue. Potential applications
of electrospun nanofibers for stem cell differentiation are envisioned in the fields of
skin, bone, cartilage, blood vessels, cardiovascular diseases, nerves, and soft tissues.
5.1.2 Electrospun Nanoparticle Incorporated Natural Polymeric Scaffolds
5.1.2.1 Collagen Collagen is a fibrous protein found in animals, especially in the
flesh and connective tissues of mammals. It is the most abundant protein in
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