Biomedical Engineering Reference
In-Depth Information
FIGURE 4.15
Fluorescent imaging of osteoblast cells revealing a well-developed cyto-
skeleton with strong actin stress fibers oriented in the adhered cells in their longitudinal
direction.
When the sintered ceramic was coated five times after the porous network had been
made, the porosity decreased to 65%. The compressive strength was strongly
dependent on the porosity and weakly dependent on the type of ceramics (i.e.,
HA, TCP, or HA-TCP composite). At a 65% porosity level, the strength was
3MPa. The TCP exhibited the highest dissolution rate in Ringer's solution
with HA exhibiting the lowest rate. The biphasic HA-TCP composite showed an
intermediate dissolution rate. The biodegradation of calcium phosphate ceramics
could be controlled by simply adjusting the amount of HA or TCP in the ceramic.
4.9 OUTSTANDING ISSUES
Although available literature, as summarized above, provides details on synthesis,
properties and different applications of porous scaffolds, it is quite clear that porous
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