Biomedical Engineering Reference
In-Depth Information
Table 17.1
Protein information sources for Targetpedia
Name
Description
Example sources
General
functional
information
General textual summary
of the target
Wikipedia [3]
EntrezGene [6]
Gene Ontology [10]
Chromosomal
information
Key facts on parent gene
within genome
Ensembl [4]
Disease links
Known disease associations
Genetic Association
Database [11]
OMIM [12]
Literature associations
(PMx)
GWAS data (e.g. [13])
Genetics
Polymorphisms and mouse
phenotypes
Polyphen 2 [14]
Mouse Genome Informatics
[15]
Internal data
Literature mining (PMx)
Drug discovery
Competitor landscape for
this target
Multiple commercial
competitor databases [2]
Safety
Safety issues
Comparative
Toxicogenomics
Database [16]
Pfi zer safety review
repository
Literature mining (PMx)
Pfi zer project
information
Projects have we worked on
this target for
Discovery and Development
portfolio databases
Pfi zer screening registration
database
References
Key references
Gene RIFs [6]
Literature mining (PMx)
Pathways
Pathways is this protein a
member of
Reactome [17]
BioCarta [18]
Commercial pathway
systems
Loading data
Having identifi ed the necessary data, a methodology for loading this into
the Targetpedia was designed and implemented, schematically represented
in Figure 17.1 and discussed below.
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