Biomedical Engineering Reference
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associated compounds from within individual projects or across projects,
known as a DesignSet. Candidate compounds associated with a design
hypothesis can be prioritised and proposed for synthesis. Synthetic
chemists are assigned and it is they who then progress the compounds
(and associated design hypothesis) through the complete synthetic work
on the design hypothesis. Figure 12.1 shows a sample DesignSet, which
includes the hypothesis and proposed compounds; in this case four
compounds have been requested and two are currently in synthesis. The
compounds are automatically assigned as registered once they appear in
the AstraZeneca compound collection and can then be sent for testing.
Analysis of the data is then performed by scientists for the specifi c design
hypothesis and the outcome is captured. Based on the outcome and
learning, a further round of the DMTA cycle can be started.
Design Tracker stores projects, design hypotheses and compounds in a
database together with associated data and creates automated mappings
Figure 12.1
A sample DesignSet
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