Biomedical Engineering Reference
In-Depth Information
which are seeing signifi cant adoption in other areas of the life sciences
too, including drug discovery, text mining, and neurosciences [35-37].
Several other chapters in this topic describe applications making use of
semantic web technologies. In particular David Wild's work in creating
the Chem2Bio2RDF framework (Chapter 18) and the chapter by Bildtsen
and co-authors in the development of the 'triple map' application
(Chapter 19). In addition, the chapters by Alquier (Chapter 16) and by
Harland and co-authors (Chapter 17) describe application of semantic
MediaWiki in life science knowledge management. The OpenTox
platform has demonstrated the provision of a simple but well-defi ned and
consistent ontology for the interaction with their services, providing
functionality for both service discovery and service invocation. The SADI
framework is the only known semantic alternative [38], but does not
currently provide the same level of computational toxicology services as
does OpenTox.
The combination of these two unique features makes it possible for
Bioclipse-OpenTox to follow the evolution of computational toxicology
closely and promptly. We are therefore delighted that this topic chapter
is available under a Creative Commons ShareAlike-Attribution license,
allowing us to update it for changes in the Bioclipse-OpenTox
environment.
2.6 Availability
Bioclipse with the Decision Support and OpenTox extensions can be
freely downloaded for various platforms from
http://www.bioclipse.net/
opentox
.
2.7 References
[1] European Parliament - European Commission. Regulation (EC)
No. 1907/2006 of the European Parliament and of the Council.
Offi cial
Journal of the European Union
2006.
[2] Knudsen TB, Houck KA, Sipes NS, et al. Activity profi les of 309
ToxCast™ chemicals evaluated across 292 biochemical targets.
Toxicology
2011;282(1-2):1-15.
[3] Schmidt U, Struck S, Gruening B, et al. SuperToxic: a comprehensive
database of toxic compounds.
Nucleic Acids Research
2009;37(Database
issue):D295-9.
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