Biology Reference
In-Depth Information
Michaelevski et al. (2010).
Smith et al. (2011).
Bhlhe40
Stat1,2,4,5
Gata4
HIF-1
NF-1
Brca1
Irf1
Klf6
NR2A2 TBP
Chd4
Cebpz
HMGY
Pax-2
Pax-6
Myc
(Gata)
Rfc1
HNF1
Ebf1
Mzf1
AhR
Rnf38
HNF4
JunB
PPAR
α
Ftsjd2
Usf2
Stat3
Stat6
Nr3c1
Nr5a1
AP-2
Sfpi1
RBP-J
K
Gata3
Hdgfrp2
CAR1
c-Myb
ER-
α
FOXO1a
Smad4
Stat1
JunD
Smad3
Sp1
Psip1
Max
Hif1a
Rdbp
Tcfap4
MAZ
MyoD
SRF
Ikzf1
Rela
Usf1
FOXO3a
Usf2
FOXO4
(Smad)
Fos
Egr1
Jun
Yy1
(Klf)
Atf3
Sin3b
ATF4
Gilz
Hmgb1
Sox10
Brn3b
Ankrd1
Tceb1
Crem
Cdc5l
Madh1
Tcf19
Tcf8
Onecut1
Fra-2
Csda
Csen
Mafb
(Sox)
Smad1
hoxd1
Nfil3
Nfyb
Tle3
Sox11
zfp367
Isl1
Krox4
Csrp3
Isl2
Dbp
Nhl-2
zfp655
Drg11
EST(1)
Rab7
zfp91
Shox2
EST(2)
EST(3)
Zou et al. (2009).
Stam et al. (2007).
Figure 3.1 A comparison between four lists of transcription factors and transcriptional
modulators predicted to be active in DRG neurons as they regenerate axons. Symbols in
parentheses indicate cases in which nonidentical members of the same gene family
were identified by multiple datasets. Details of sample preparation and time points
are available in
Table 3.1
.
transcription factors despite differences in methodology and model systems
(
Fig. 3.1
). However, more than 100 factors are unique to only one set,
highlighting the need for additional studies and approaches to achieve con-
sensus regarding the transcriptional control of PNS regeneration.
4.3.
screening of PNS injury-induced genes
Functional screens are emerging to complement the profiling and bioinfor-
matics efforts described earlier. For instance, the study by
Smith et al. (2011)
screened 25 PNS-enriched transcription factors for the ability to increase
In vitro
