Consequences of Elastolysis - Extracellular Matrix Degradation - page 233

Table 9.1 Substrate specificity of selected elastases
Substrate NE PR3 MMP2 MMP3 MMP7 MMP9 MMP10 MMP12 Cat S Cat L Cat K

Elastin

þ þ þ þ þ þ þ þ þ þ þ

Aggrecan

þ þ þ þ þ þ

Brevican

þ

Collagen I

þ þ þ þ þ þ þ þ

Collagen III

þ þ þ þ þ þ

Collagen IV

þ þ þ þ þ þ þ þ

Collagen V

þ þ þ þ

Entactin

þ þ þ þ þ

Fibrillin

þ þ þ þ

Fibronectin

þ þ þ þ þ þ þ þ þ þ

Fibulin

þ þ

Gelatin

þ þ þ þ þ þ þ þ þ þ

Laminin

þ þ þ þ þ þ þ þ þ þ

Vitronectin

þ þ þ þ þ þ

A1AT

þ þ þ þ þ

2-macroglobulin

a þ þ þ þ

Pro-TNF a þ þ þ þ þ

Plasminogen þ þ þ þ þ

TIMPs þ

Reviewed in (Chapman et al. 1997 ; Sternlicht and Werb 2001 ; Hedstrom 2002 )