Matrix Metalloproteinases and Their Inhibitors in Turnover and Degradation of Extracellular Matrix - Extracellular Matrix Degradation - page 3

Table 1.1 Mammalian matrix metalloproteinases
Designation a Common name(s) ECM or ECM-

related substrates b

Citations

MMP1 Collagenase-1 Fibrillar collagens Pilcher et al. ( 1997 ) and many

others Mcol-A, Mcol-B c

MMP2 Gelatinase-A Fibronectin Kenny et al. ( 2008 )

72-kD gelatinase Vitronectin

MMP3 Stromelysin-1 Laminins Sympson et al. ( 1994 )

Type IV collagen

MMP7 Matrilysin Syndecan-1 Li et al. ( 2002 )

Elastin Filippov et al. ( 2003 )

MMP8 Collagenase-2

Neutrophil collagenase

MMP9 Gelatinase-B Fibrin Lelongt et al. ( 2001 )

NG2 proteoglycan Larsen et al. ( 2003 )

92-kD gelatinase Elastin Kenny et al. ( 2008 ), Longo et al.

( 2002 ), Pyo et al. ( 2000 )

-dystroglycan Michaluk et al. ( 2007 )

b

MMP10 Stromelysin-2

MMP11 Stromelysin-3

MMP12 Metalloelastase Elastin Hautamaki et al. ( 1997 )

Houghton et al. ( 2006 )

MMP13 Collagenase-3 Fibrillar collagens

(type II)

Stickens et al. ( 2004 )
Inada et al. ( 2004 )

MMP14 MT1-MMP Fibrillar collagens Holmbeck et al. ( 1999 ), Hotary

et al. ( 2000 ), Hotary et al.
( 2002 )

Fibrin Hotary et al. ( 2002 )

Syndecan-1 Endo et al. ( 2003 )

MMP15 MT2-MMP Fibrin Hotary et al. ( 2002 )

MMP16 MT3-MMP Fibrillar collagens Shi et al. ( 2008 )

Fibrin Hotary et al. ( 2002 )

Syndecan-1 Endo et al. ( 2003 )

MMP17 MT4-MMP

MMP19 RASI-1

MMP20 Enamelysin Amelogenin Caterina et al. ( 2002 )

MMP21
MMP22
MMP23 CA-MMP

MMP24 MT5-MMP

MMP25 Leukolysin

MMP26 Endometase, Matrilysin-2

MMP27
MMP28 Epilysin
a MMP4, 5, and 6 turned out to be either MMP2 or MMP3. MMP18 (collagenase-4) has only been
cloned from Xenopus . A mammalian homologue has not been found
b If left blanked, then a physiologic ECM substrate has not been identified and validated by genetic
approaches or detailed cell-based models
c Mcol-A and -B are murine homologues of MMP1 (Balbin et al. 2001 )