Biomedical Engineering Reference
In-Depth Information
Fig. 6.8
Lipid bilayer forma-
tion in the presence of particles
smaller than the lipid bilayer
thickness.
a
An AFM image of
the sample in the initial stage
(no lipid) with a 3.4nm diam-
eter particle,
b
a lipid bilayer
formed on the substrate with a
3.4nm diameter particle with
corresponding schematics in
c
,
d
AFM topography after
adsorption of an insulin mole-
cule onto the particle through
the hole in SLB (schematic
is in
e
),
f
an AFM image of
the substrate with a 1.2nm
diameter particle (no lipid),
g
topography of the formed
lipid bilayer over a 1.2nm
diameter particle (schematics
is in
h
), and
i
image after
the injection of insulin (no
changes in topography). This
figure with its description
has been taken with the pub-
lisher's permission from [
22
]
some unique characteristics. The first ever observed triangular conductance events
opment of novel nanotechnology applications (see Fig.
6.10
). The independent tri-
angular conductance events suggest that the conductance in a single event is not
constant, but increases/decreases spontaneously over the time interval comparable
to the low millisecond (ms) order 'lifetime' of any specific conductance event. The
amplitudes of these events are also different. We observed random spontaneous tran-
sitions between different current levels within a discrete conductance event during
its lifetime. These discrete events were found to be approximately characterized
by conductance values of
5-30 ms.
A spontaneous transition or a time-dependent current fluctuation between random
∼
0
.
01-0
.
1 pA/mV and lifetimes in the range
∼
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