Biomedical Engineering Reference
In-Depth Information
80
80
200
200
1st
1st
2nd
2nd
60
150
60
150
40
40
100
100
20
20
50
50
0
0
0
0
0.0000
0.0025
0.0050
0.0000
0.0025
0.0050
q
L
/
q
Alm
q
L
/
q
gA
Fig. 5.20
q
Alm
(
right panel
)inlipid
bilayer energetic in the first- and second-order of lipid screening. Here,
r
LL
=
7
.
74597 Å
Plot of
G
I
,
II
as a function of
q
L
/
q
gA
(
left panel
)or
q
L
/
gA
Alm
50
50
40
40
1st
40
40
2nd
30
30
30
30
1
st
20
20
2
nd
20
20
10
10
10
10
6.5
7.0
7.5
6.5
7.0
7.5
Fig. 5.21
G
I
,
II
as a function of
r
LL
for the gA channel (
left panel
) and the Alm channel
(
right panel
) in lipid bilayer energetics in the first- and second-order of lipid screening, respectively.
Here,
q
L
Plot of
/
q
M
=
0
.
0025
5.6 Fitting Theoretical Predictions to Experimental Results
The experimental results presented in Sect.
5.4
show that the gA channel's lifetime
τ
decreases drastically as the bilayer thickness increases, and at a sufficiently high
thickness, the gA channel structure experiences a conformational transition. The
trend in the value of
τ
in a PC bilayer shows that it decreases almost exponentially
with the increase of bilayer thickness. A recent study [
6
] has also supported this
conclusion that
τ
decreases almost exponentially with the increase of the bilayer-
channel hydrophobic mismatch. Within a reasonable approximation, since it can
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