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clonal selection algorithm( )
1. Initialization
Create initial random population of antibodies P
2. Antigenic presentation
while not stopping criterion met do
for each antigen do
2.1. Affinity evaluation
present current antigen to current antibody
population P
for each antibody do
compute antibody affinity with current antigen
2.2. clonal selection and expansion
select a subset of antibodies in P with highest
affinities
generate exact copies (clones) of antibodies with
highest affinities according to their affinities,
the higher the affinity, the higher the number of
clones
2.3. affinity maturation
mutate all clones at a rate inversely proportional to
their affinities with current antigen
add mutated antibodies to P and re-select the best
individuals to keep them as the memory of current
antigen
2.4. metadynamics
replace antibodies with lowest affinities by randomly
generated new antibodies
Figure 5.2
Description of the generic clonal selection algorithm.
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