Blood Cells - Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems - page 58

Tabl e 3. 3. Scaffold proteins in immune system signaling (Source: [ 99 ]; ASC:
apoptosis-associated speck-like protein containing a caspase activation and recruitment domain
[CARD]; BCL: B-cell lymphoma; CARMA: CARD-MAGUK domain-containing protein; CBL:
Casitas B-lineage lymphoma; CDC: cell-division cycle; CTAK: CDC25c-associated kinase;
DLg: disc large homolog; ERK: extracellular signal-regulated kinase; GSK: glycogen-synthase
kinase; HSP: heat shock protein; IP 3 R: inositol trisphosphate receptor; IRAK: interleukin-
1-receptor-associated kinase; JNK: Jun N-terminal kinase; KSR: kinase suppressor of Ras;
MAGUK: membrane-associated guanylate kinase; MALT: mucosa-associated-lymphoid-tissue
lymphoma-translocation gene; MAP2K: mitogen-activated protein kinase kinase; MyD: myeloid
differentiation primary-response gene; NF B-inducing kinase,

or MAP3K14; NLR: nucleotide-binding domain and leucine-rich-repeat-containing receptor;
NLRP: NLR/pyrin-domain-containing; PLC: phospholipase-C; PKC: protein kinase-C; PP:
protein phosphatase; RSG: regulator of G-protein signaling; S100: S100 calcium-binding protein;
SMAD: small mothers against decapentaplegic homolog; STAT: signal transducer and activator
of transcription; SuGT: suppressor of G2 allele of S-phase kinase-associated protein SKP1; TAK:
TGF β -activated kinase, or MAP3K7; TCR: T-cell receptor; TGF: transforming growth factor;
TLR: Toll-like receptor; TNFR: tumor-necrosis factor receptor; TRAF: TNFR-associated factor;
WASP: Wisk ott-Aldrich syndrome protein; ZAP: ζ -chain-associated protein kinase) .

κ B: nuclear factor- κ B; NIK: NF κ

Scaffold proteins Binding partners

Ahnak1 Calcium channels, caveolin-1,

PKC, PLC γ , S100a

BCL10 CARMA1, MALT1, TAK1 (MAP3K7),

MAP2K7, JNK2

DLg1 CBL, LCK, Vav1, WASP, ZAP70,

P38MAPK

Homer IP 3 R, Homer,

group-1 metabolic receptors

KSR CDC37, CTAK1, PP2a, 14-3-3, HSP70, HSP90,

Raf, MAP2K1, ERK

NLRP ASC, HSP90, SuGT1,

caspase-5, BCL2, BCLxL

Pellino BCL10, IRAK1/4, MyD88, NIK (MAP3K14),

(Ub ligase) SMAD6, TAK1, TRAF6

F actin, PP1, RGS

Spinophilin

(PP1 r9 )

(LAT), B-cell linker (BLnk), 9 and lymphocyte cytosolic protein LCP2 [ 99 ]. 10 These
scaffolds can be phosphorylated (hence their names “tyrosine phosphoproteins”).

9 A.k.a. B-cell adapter containing a SH2 domain protein (BASH), 65-kDa SH2 domain-containing
leukocyte protein (SLP65), and lymphocyte antigen Ly57 homolog.
10 A.k.a. 76-kDa SH2 domain-containing leukocyte protein (SLP76).