Biomedical Engineering Reference
In-Depth Information
stimulate or inhibit IGF1. Insulin-like growth factor binding protein IGFBP3 carries
IGF1 and IGF2 in blood. The auto- and paracrine IGFBP3 activity influences cell
adhesion, survival, motility, division, and apoptosis. Synthesis of IGFBP3 increases
during hypoxia. Protein IGFBP3 enhances or prevents angiogenesis depending on
the context: it favors endothelial cell migration and capillary formation, but reduces
preretinal neovascularization. Hypoxia-induced IGFBP3 promotes the recruitment
of progenitors into remodeling regions (at least in the retina). Agent IGFBP3
targets CD34
cells involved in inflammation
associated with vascular repair) that quickly differentiate into endothelial cells.
+
endothelial precursors (not CD14
+
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