Vasculature Growth - Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems - page 620

Table 10.9. Family of tenascins (Ten). These matrix, cell adhesion glycoproteins act via integrins,
cell adhesion molecules of the immunoglobulin superfamily (IgCAMs), protein Tyr phosphatase
receptor PTPRz1, annexin-2, fibronectin, and matrix proteoglycan lectican. The tenascin family
includes TenC, TenR, TenW, TenX, and TenY. Tenascins can have anti-adhesive effects. Tenascin-
C can promote integrin-dependent protein clustering at focal adhesions, as it interacts with RTKs
and activates ERK. Like TenC, TenX (or flexilin) is expressed in the heart as well as vascular
smooth myocytes. TenY is coexpressed with TenC in the lungs.

Tenascin Alias

TenC Cytotactin

TenR Restrictin, janusin

TenW
TenX Flexilin, hexabrachion

TenY

Table 10.10. Family of fibulins (Fbln [Fibl]; ARMD: age-related macular degeneration; AxPC1:
ataxia, posterior column 1, with retinitis pigmentosa; DANCE: developmental arteries and neural
crest EGF-like protein; DHRD: Doyne honeycomb retinal dystrophy (macular degeneration)
protein; EFEMP: EGF domain-containing fibulin-like extracellular matrix protein). Fibulins
regulate organ shape with growth factors and stromal cells. They are involved in cell proliferation,
migration, differentiation, and survival.

Type Other aliases

Fbln1 Fibl1

Fbln2 Fibl2

Fbln3 Fibl3, EFEMP1, DHRD

Fbln4 Fibl4, EFEMP2

Fbln5 Fibl5, DANCE

Fbln6 Fibl6, hemicentin-1 (Hmcn1), ARMD1, AXPC1

Fbln7 Fibl7

10.5.4 Fibulins

Fibulins (Fbln1-Fbln7; Table 10.10 ) constitute a family of secreted calcium-binding
glycoproteins that are encoded by 7 genes. They interact with several matrix
proteins, such as fibrillin, fibronectin, laminins, proteoglycans, and tropoelastin.
Fibulin-1 is associated with elastic fibers. It lodges particularly in basement
membranes. It is also present in blood, where it binds to fibrinogen. It is in-
corporated in fibrin clots. Fibulin-1 suppresses fibronectin-mediated adhesion and
motility [ 1199 ].
Fibulin-2 is involved in microfibril and elastic fiber organization [ 1200 ]. It can
participate in clusters made of nidogen-1 and -2, fibronectin, and perlecan, a
major heparan sulfate proteoglycan in the basement membrane that possesses
immunoglobulin-like modules (IG2-IG15) with many binding sites for cellular and
extracellular ligands [ 1201 ].