Vasculature Growth - Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems - page 616

Table 10.6. Examples of matrikines in inflammation and angiogenesis (Source: [ 1185 ]; I:
integrin; SPARC: secreted protein acidic and rich in cysteine; Tsp: thrombospondin). Matrikines
are fragments of matrix constituents generated by proteolytic cleavage with functions distinct from
those of parental proteins.

Matrikine Source Receptor Function

Anastellin Fibronectin Anti-angiogenic

α V β 3 , α 9 β 1 -I

Angiostatin Plasminogen Anti-angiogenic

Arresten Collagen-4 α 1 β 1 -I Anti-angiogenic

Canstatin Collagen-4 Anti-angiogenic

Endorepellin Perlecan Anti-angiogenic

Endostatin Collagen-18 α V β 3 -I Anti-angiogenic

Metastatin Collagen-4 Anti-angiogenic

Neostatin Collagen-18 Anti-angiogenic

Tumstatin Collagen-4 α V β 3 , α 5 β 1 -I Anti-angiogenic

Vastatin Collagen-8 Anti-angiogenic

Restin Collagen-15 Anti-angiogenic

Peptides from Elastin Pro-angiogenic

Peptides from SPARC Pro/anti-angiogenic

Peptides from Tsp Pro/anti-angiogenic

Peptides from Collagens-1/4, Elastin-binding protein, Chemotactic

elastin, L-selectin,

fibronectin, integrins,

laminins, CXCR1/2

entactin, Tsp,
hyaluronan

10.5.2 Protein Fragments and Peptidases of the Extracellular

Matrix

Proteic constituents and peptidases of the extracellular matrix contribute to angio-
genesis. Released active fragments of cleaved matrix constituents, the so-called
matrikines , are involved in the control of angiogenesis and healing (Table 10.6 ).
Most of the matrikines compete with intact matrix components for interaction with
integrins.
Many matrikines have an anti-angiogenic effect. They derive from components
of: (1) the basement membrane, such as collagen-4, 15 perlecan, 16 and fibronectin, 17

15 A.k.a. arresten, canstatin, metastatin, and tumstatin.
16 A.k.a. endorepellin.
17 A.k.a. anastellin.