Hematopoiesis - Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems - page 33

Tabl e 2. 3. : no expression).

Cell-surface marker CD34 enables the identification of hematopoietic stem cells and progenitors.
CD34-related proteins include podocalyxin and endoglycan.

Distribution of CD34 family members (Source: [ 66 ]; + : expression; −

Distribution CD34 Podocalyxin Endoglycan

Multipotent precursors + + +

Eosinophils + − −

− −

Erythrocytes Anemia

− −

T lymphocytes Thymocytes

B lymphocytes − − TLR-activated B cells

Macrophages − − −

Mastocytes + − −

Thrombocytes − + −

Muscle satellite cells + − −

Hair follicle stem cells + − −

Vascular endothelia + + +

Smooth myocyte − − +

Fibrocytes + − −

Mesothelia − + −

Neurons Weak + Some

Podocytes − + Weak

Tabl e 2. 4. Regulators of hematopoiesis. Canonical Wnt and Jagged-1-Notch-1 signaling promote
HSC survival and proliferation particularly after damage. Insulin-like growth factor binding
protein-3 (IGFBP3) favors progenitor recruitment to hypoxic sites (CSF: colony-stimulating factor;
CSFR: colony-stimulating factor receptor; LRP: LDL receptor-related protein).

Factor Receptor and

partners

Erythropoietin EpoR

Granulocyte CSF (CSF3) CSF3R; Ras

Granulocyte-macrophage CSF (CSF2) CSF2R; Ras

IGF1 IGF1R; IGFBP3

Interleukins ILR

Jagged-1 Notch

Macrophage CSF (CSF1) CSF1R; Ras

Sonic Hedgehog Patched

Stem cell factor SCFR

Thrombopoietin TpoR

Tumor-necrosis factor- α TNFR

Wnt Frizzled, LRP; Disheveled,

β -catenin

STAT JaK