Vascular Endothelium - Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems - page 498

Only P130 Amot localize to adherens junction. It binds to scaffold membrane-
associated guanylate kinase-related protein with inverted domain organization
MAGI1b. Only P130 Amot binds to actin [ 920 ].
Isoforms P80 AMot and P130 AMot homo- and heterodimerize [ 920 ]. In addition,
P80 AMot colocalizes with the early endosome marker EEA1 (or ZFYVE2) as well
as with the RhoGEF PlekHg5, with ARF6 and Rab11 in perinuclear recycling
endosomes, and with Rab13 GTPase.

9.5.8.3 EGFL7

Multiple EGF-like domain-containing protein EGFL7, or veStatin, is exclusively
secreted by endothelial cells to modulate smooth myocyte migration. It may also
be involved in the spatial organization of endothelial cells in the angiogenic sprout.
It impedes deposition and organization of elastic fibers [ 921 ]. 58 This inhibitor of

vascular elastogenesis interacts with lysyl oxidase. 59

9.5.8.4 Endosialin

Angiogenic endosialin 60 expressed in endothelium binds to fibronectin 61 and
collagen-1 and -4 to enhance cell-matrix adhesion and cell migration [ 922 ].
Endosialin in cells of tumor stroma and endothelium favors tumor angiogenesis
and invasion. Endosialin enhances MMP9 activity. In addition, endosialin regulates
pericyte-endothelial cell interactions, as its expression is also associated with
pericytes.

58 Elastic fibers are stable components of the extracellular matrix that strongly participate in
rheology of blood vessel walls. Elastic are fibers composed of a core of elastin assembled onto
a microfibrillar scaffold made of several proteins, such as fibrillins, fibulins, emilins, and MAGPs.
Fibroblasts, smooth myocytes, and endothelial cells, among other cells, secrete tropoelastin, which
is deposited on the pre-assembled microfibrillar scaffold. Adjacent tropoelastins spontaneously
aggregate then crosslink to form elastin polymers owing to the copper-dependent family of lysyl
oxidases.
59 The family of lysyl oxidases comprises 5 known members (Lox, LoxL1-LoxL4). They crosslink
several ECM components, such as elastin and collagens.
60 A.k.a. tumor endothelial marker TEM1, CD164 sialomucin-like protein-1 (CD164L1), and
CD248.
61 Fibronectin interacts with many plasmalemmal receptors and components of the extracellular
matrix. Integrin-

α 4 β 1 and - α 5 β 1 also mediate fibronectin-dependent cell adhesion.