Cardiomyocytes - Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems - page 219

Tabl e 5. 4. The PDZ-LIM family of scaffold proteins or kinases. In the heart, members of this
family intervene during embryogenesis as well as adaptive remodeling in response to mechanical
stresses and strains.

Type Alias(es)

Class-1

PDLIM1 Elfin, CLIM1, CLP36

PDLIM2 Mystique, SLIM

PDLIM3 ALP

PDLIM4 RIL

LMO7 FBx20

Class-2

LIMK1
LIMK2

Class-3

PDLIM5 EnH (EnH1)

PDLIM6 Cypher, ZASP, LDB3, Oracle

PDLIM7 Enigma, LMP1

LMP4

5.3.5.6 Members of the PDZ-LIM Family

The PDZ-LIM protein family 48 contains 10 known members that serve as scaf-
fold proteins. These cytoplasmic proteins bind to the cytoskeleton via

-actinin.
The PDZ-LIM family can be subdivided into 3 classes according to the number
of LIM domains (Table 5.4 ). PDZ and LIM domain-containing protein PDLIM1
possesses a single C-terminal LIM domain. On the other hand, PDLIM5 (or Enigma
homolog) and PDLIM7 (Enigma) contain 3 LIM domains. In the heart, PDZ-
LIM family members act as adaptors that connect mechanical sensors embedded
in specialized cytoskeletal structures such as the Z disc, to signaling mediators.

α

Categories of PDZ-LIM Proteins

Group- 1 PDZ-LIM proteins that have a single PDZ domain and a single LIM
domain include: (1) PDLIM1, 49 (2) PDLIM2, 50 (3) PDLIM3, 51 (4) PDLIM4, 52 and

48 Aliases PDZ and LIM correpond to the first 3 identified PDZ proteins — PSD95 (a.k.a. DLg4
and SAP90), septate junction proteins Disc large homolog, and zonula occludens ZO1 — and the
first 3 described LIM domain-containing proteins — Lin11, Isl1, and Mec3, respectively.
49 A.k.a. Elfin, C-terminal LIM domain-containing protein CLIM1 and CLP36.
50 A.k.a. Mystique and SLIM.
51 A.k.a. actinin-associated LIM protein (ALP).
52 A.k.a. reversion-induced LIM protein (RIL).