Biomedical Engineering Reference
In-Depth Information
Table 3.27.
Agents
for
development
and
maintenance
of
T-lymphocyte
populations
(Source:
[
225
];
Itch: Itchy
homolog
[ubiquitin ligase];
TGF: transforming
growth
factor).
Interleukin-25 re
gulates both T
H2
and T
H9
cell populations.
Subset
Released effectors
Agents for development and maintenance
γδ
γ
Released Ifn
, IL17a/f, IL22
CD8
αα
Released IL10, TGF
β
T
H1
, IL2, TNFSF2
Developmental regulator IL12
Released Ifn
γ
T
H2
Released ILs4/5/10/13
Developmental regulators ILs4/25/33
T
H9
Released ILs9/10
Developmental regulators ILs4/25, TGF
β
T
H17
Released IL17a/f, IL21/22/26, CCL20
Developmental regulators IL6/21, TGF
β
Maintenance regulators IL1/23
T
H22
Released IL22
T
FH
Released IL21
Central memory
IL2, TNFSF5, low levels IL4, Ifn
γ
, IL17a
Cytotoxic
Perforin, granzyme, Ifn
γ
T
R1
Released IL10
Developmental regulators TGF
β
,IL27
nT
Reg
Released IL10/35, TGF
β
iT
Reg
Released IL10, TGF
β
NKT
Released IL4/17a, Ifn
γ
Anergic
GRAIL, CBLb, Itch, NEDD4
The transcription factor T
H
-inducing POZ/Kr uppel-like factor THPOK
114
is
required after initial lineage specification for the differentiation of CD4
+
helper
T cells from double-positive CD4
thymocytes. Overexpression of THPOK
(ZBTB7b) converts MHC class-1-restricted CD8
+
,CD8
+
+
T cells into MHC class-2-
restricted CD4
+
T cells, whereas THPOK repression redirects CD4
+
T cells to the
CD8
lineage commitmemt.
Regulator GATA3 acts upstream from THPOK to initiate CD4
+
lineage [
227
]. Regulator THPOK represses the CD8
+
+
specification,
whereas THPOK serves to stabilize the CD4
fate [
228
,
229
]. Factor GATA3 is
necessary for THPOK expression in double-positive thymocytes.
The development of CD8
+
cytotoxic T-cell requires Runx1 and Runx3 tran-
scription factors. Both CD4 and THPOK are inhibited in CD8
+
cytotoxic T cells.
Conversely, THPOK represses the expression of Runx3 and other molecules of
+
114
A.k.a. zinc finger and BTB domain-containing protein ZBTB7b, zinc finger protein ZNF857b,
and Kruppel-related zinc finger protein KRox.
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